Paraproteinemia and Kidneys – from Henry Bence Jones till now days
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Paraproteinemia and Kidneys – from Henry Bence Jones till Now Days
Urol Nephrol Open Access J 2016, 3(3): 00078 On addition of nitric acid, it effervesces, assumes a reddish hue, and becomes quite clear, but as it cools, assumes the consistency and appearance which you see. Heat reliquifies it. What is it?” Dr Henry Bence Jones tested the urine sample himself and presumed that the substance, defining unusual properties is “deutoxide of albumin”. Now we know th...
متن کاملHenry Bence Jones--physician, chemist, scientist and biographer: a man for all seasons.
The name Bence Jones is recognized today as the name of a protein excreted by patients with multiple myeloma. It is ironic that Bence Jones was not the first to describe the characteristics of the protein, but he recognized its place in the diagnosis of myeloma when he wrote, `I need hardly remark on the importance of seeking for this oxide of albumen in other cases of mollities ossium' (Bence ...
متن کاملMetabolism of Bence Jones Proteins.
Bence Jones proteins are molecules of about 40,000 mol wt present in the urine of many patients with plasma cell malignancy. These microglobulins, which are synthesized in plasma-cell tumors (1, 2), share many immunochemical and physicochemical features with the larger 6.6 S y-globulins. That Bence Jones proteins are similar to or identical with components of the larger y-globulins has been sug...
متن کاملBence Jones proteinuria and myeloma kidney.
Bence-Jones proteinuria refers to urinary excretion of monoclonal light chains. It results from exclusive production of one light chain, or the unbalanced synthesis of heavy and light chains, with the latter being in excess. Free Kor A-light chains are therefore excreted alone or in addition to complete immunoglobulin molecules carrying the same light chain type. Free light chains are low molec...
متن کاملWhat's in a name? Bence Jones protein
Plasma cell disorders are important in the differential diagnosis of acute kidney injury and of renal impairment with proteinuria. One or more of several mechanisms can be involved, such as cast nephropathy, deposition of monoclonal immunoglobulins, formation of amyloid fibrils, hypercalcaemia, hyperuricaemia and a variety of tubular syndromes. Various tests, such as serum electrophoresis and i...
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ژورنال
عنوان ژورنال: Urology & Nephrology Open Access Journal
سال: 2016
ISSN: 2378-3176
DOI: 10.15406/unoaj.2016.03.00078